http://en.wikipedia.org/wiki/Psychosis
http://bjp.rcpsych.org/cgi/content/full/181/4/271
Dopamine and antipsychotic drug action revisited
H. M. JONES, MRCPsych and L. S. PILOWSKY, MRCPsych
Institute of Psychiatry, London, UK
A reasonable goal for effective, less-toxic treatment of schizophrenia is the regionally sensitive stabilisation of dopamine function, and not the blunderbuss dopaminergic paralysis induced by classical antipsychotic drugs. This selective targeting could come about by exploiting behaviour intrinsic to compounds with low D2 affinity, by designing compounds selective for dopamine receptor subtypes found at greater densities in limbic or cortical regions (for example D3 receptors), or by modulating dopamine release through action at alternative systems (novel candidates include serotonin, sigma and glutamate receptor sites).
http://en.wikipedia.org/wiki/Sanjay_Gupta
